Direct measurement (fluorimetric) of cardiovascular disease marker homocysteine in human blood plasma
- Optical sensor for measuring homocysteine directly and selectively in human plasma.
- Proof-of-concept has been established with spiked human blood samples.
- Clinical validation of the optical sensor has been performed with cardiac patient samples.
- Cell-line based bio-imaging and toxicity (MTT) data available.
- Gold standard validation of the developed sensors for sensitivity and specificity.
Lab level (gram scale)
Measurement of homocysteine concentration in human blood functions as the single largest risk marker for heart diseases and strokes. Indian market desperately looking for indigenous point-of-care assay for measuring plasma homocysteine with extreme specificity. No indigenous kit is available in India to measure homocysteine directly in human plasma. All available kits are imported and can only perform indirect measurement. We, at CSIR-CSMCRI, have developed a sensor that can measure homocysteine with absolute specificity in human plasma directly.
N/A
Hydroxycoumarin, hexamine, acetic acid, diethyl ether, substituted diamine, copper nitrate, and methanol.
None
Available on request
Know-how for homocysteine specific optical sensor; Demonstration of the synthesis of probe and diagnostic process; License fee and other financial details are available on request.
