CSMCRI/CSIR has developed a green brominating reagent (BR-S), an alternate to liquid bromine this reagent could be used for the preparation of various bromo-products such as 4-nitrobenzyl bromide PNBR (used as a protecting group in the synthesis of Penicillin and peptides), tetrabromobisphenol-A TBBP-A (widely used as a fire retardant), tri-bromoaniline TBA (dye intermediate), N-bromosuccinimide NBS (selective bromination source), bromobenzene (intermediate in the synthesis of various pharmaceuticals & fine chemicals) and bromoxynil (selective contact herbicide).
The use of BR-S, depends upon the number of bromide (Br) atoms to be substituted for a substrate, that many equivalents should be used. (Ex. For PNBR, TBBP-A, TBA, the BR-S required will be 1, 4, 3 equivalents respectively).
Replacement of the corrosive elemental bromine
Safe, easy to handle & transport
Avoids the need of special equipment
Avoids need of catalyst
Maximum bromide atom efficiency
Operates under ambient reaction conditions
Easy to scale-up for the processes’ development
No formation of hazardous byproducts
Bromo-compounds manufacturers, ready at batch scale demonstration
The process does not generate hazardous by-products. The effluent could be discharged after neutralization.
Desired organic substrate, brominating reagent, mineral acid
Glass reactor of desired size/batch with refluxing and cooling facilities
The cost varies based on the compound synthesized. The cost of the product would be roughly 1.2 – 2.6 times that of raw material cost.
Preparation of non-hazardous brominating reagent and its applications in the synthesis of organo-bromo derivatives
