Fruity berry-like odour; Raspberry ketones (RK) are found to be useful to burn subcutaneous fats, dietary supplements, promoting weight loss, in skin-lightening cosmetics anti-inflammatory and anti-oxidative activities.
The present synthesis protocol reports aryl ketone using acetoacetic ester and substituted benzylic alcohols/halide using inexpensive indigenous commercially available solid acid catalyst provides convenient and efficient synthetic route of alkylation and decarboxylation
High conversion and excellent selectivity
Solvent free conditions are feasible
Process is carried out at 50g scale
The market value for aryl ketones ranks second behind vanillin, with a total potential market value (US$3000/kg). However, RK is mainly isolated from red raspberries fruits, and extractable concentration of RK is very low (1-4 mg/kg); Opportunity for “Make in India”
No effluent is generated in the process; Use of easily filterable solid catalyst; Scope to avoid solvents
Benzylic alcohols, Acetoacetic ester
Process equipment like reaction vessel with agitating assembly, distillation set-up
Techno-economically attractive as the reaction occurs in single pot using an inexpensive commercial catalyst
Process know-how for Raspberry ketone; Demonstration of the process at 100 g scale; License fee, royalty and other financial details are available on request.
