M Manna

Dr. (Mrs.) Moutusi Manna

Senior Scientist

Academic Qualifications

PhD – Chemistry, University of Calcutta, 2012, MSc – Chemistry (Physical Chemistry Specialization), University of Calcutta, 2006

Contact Details

Dr. (Mrs.) Moutusi Manna

Senior Scientist

mmanna@csmcri.res.in

mmanna@csmcri.res.in

/ 0278- 2567760 (6250 Ext.)

Scholar Google: https://scholar.google.co.in/citations?hl=en&user=NvEyN5kAAAAJ

ORCID iD: https://orcid.org/0000-0001-9472-1594

  1. Manna*, M. and Murarka*, R. K. M, Polyunsaturated fatty acid modulates membrane-bound monomeric α-synuclein by modulating membrane microenvironment through preferential interactions, ACS Chemical Neurosciences, In press, 2021  (impact factor 4.486)
  1. Manna, M., Nieminen, T. and Vattulainen, I. Understanding the Role of Lipids in Signaling through Atomistic and Multiscale Simulations of Cell Membranes, Annual Review of Biophysics  (2019) 48:421-439 (impact factor 11.685)
  1. Manna*, M. and Murarka, R. K. Characterization of conformational ensemble of C-terminally truncated α-synuclein in aqueous solution by atomistic molecular dynamics simulations, Journal of Indian Chemical Society (2019), 96: 991-1002 (impact factor 0.15)
  1. Mobarak E.; Haversen, L.; Manna, M.; Levin, M.; Perkins, R.;  Vattulainen, I.;  Rog, T.; and Jan, B. Glucosylceramide modifies the LPS-induced inflammatory response in macrophages and the orientation of the LPS/TLR4 complex in silico, Scientific Reports (2018), 8:13600 (impact factor 3.998)
  1. Manna, M.; Javanainen, M.; Monne, H. M.-S.; Gabius, H. J.; Rog, T.; and Vattulainen, I. Long-chain GM1 gangliosides alter transmembrane domain registration through interdigitation. BBA-Biomembranes (2017), 1859 (5): 870-878 (impact factor 3.411)
  1. Guixà-González, R.; Albasanz, J. L.; Rodriguez-Espigares, I.; Pastor, M.; Sanz, F.; Martí-Solano, M.; Manna, M.; Martinez-Seara, H.; Hildebrand, P., Martin, M. and Selent, J. Membrane cholesterol access into a G-protein- coupled receptor. Nature Communications (2017), 8: 14505 (impact factor 12.121)
  1. Manna, M.; Niemelä, M.; Tynkkynen, J.; Javanainen, M.; Kulig, W.; Müller, D. J.; Rog, T. and Vattulainen, I. Mechanism of allosteric regulation of β2-adrenergic receptor by cholesterol. eLife (2016), 5:e18432. (impact factor 7.080)
  1. Manna, M.; Kulig, W.; Javanainen, M.; Tynkkynen, J.;Hensen, U.; Müller, D. J.; Rog, T. and Vattulainen, I. How to minimize artifacts in atomistic simulations of membrane proteins, whose crystal structure is heavily engineered: β2-adrenergic receptor in the spotlight. Journal of Chemical Theory and Computation (2015), 11 (7): 3432-3445 (impact factor 5.313)
  1. Basu, I.; Manna, M. and Mukhpadhyay, C. Insights into the behavioral difference of water in the presence of GM1. FEBS Letters (2015), 589 (24): 3887-3892 (impact factor 3.057)
  1. Manna, M.; Rog, T. and Vattulainen, I. The challenges of understanding glycolipid functions: An open outlook based on molecular simulations. BBA-Molecular and Cell Biology of Lipids (2014), 1841 (8): 1130-1145 (impact factor 4.519)
  1. Neuvonen, M.; Manna, M.; Mokkila, S.; Javanainen, M.; Rog, T.; Liu, Z.; Bittman, R.; Vattulainen, I. and Ikonen, E. Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes. PLoS ONE (2014), 9 (8) :e103743. (impact factor 2.740)
  1. Lajunen, T.; Kontturi, L.-S.; Viitala, L.; Manna, M.; Cramariuc, O.; Róg, T.; Bunker, A.; Laaksonen, T.; Viitala, T.; Murtomäki, L.; Urtti, A. Indocyanine green-loaded liposomes for light-triggered drug release. Molecular Pharmaceutics (2016), 13 (6): 2095-2107. (impact factor 4.321)
  1. Orłowski, A.; Róg, T.; Paavilaine, S.; Manna, M.; Heiskanen, I.; Backfolk, K.; Timonen, J. and Vattulainen, I. How endoglucanase enzymes act on cellulose nanofibrils: Role of amorphous regions revealed by atomistic simulations. Cellulose (2015), 22 (5):2911-2925 (impact factor 3.90)
  1. Kulig, W.; Jurkiewicz, P.; Olżyńska, A.; Tynkkynen, J.; Javanainen, M.; Manna, M.; Rog, T.; Hof, M.; Vattulainen, I. and Jungwirth, P. Experimental determination and computational interpretation of biophysical properties of lipid bilayers enriched by cholesteryl hemisuccinate. BBA-Biomembranes (2015), 1848 (2): 422-432. (impact factor 3.411)
  1. Kulig, W.; Olzynska, A.; Jurkiewicz, P.; Kantola, A. M.; Komulainen, S.; Manna, M.; Pourmousa, M.; Vazdar, M.; Cwiklik, L.; Rog, T.; Khelashvili, G.; Harries, D.; Telkki, V.-V.; Hof, M.; Vattulainen, I. and Jungwirth, P. Cholesterol under oxidative stress- how lipid membranes sense oxidation as cholesterol is being replaced by oxysterols. Free Radical Biology and Medicine (2015), 84: 30-41 (impact factor 6.17)
  1. Kulig, W.; Tynkkynen, J.; Javanainen, M.; Manna, M.; Rog, T.; Vattulainen, I. and Jungwirth, P. How well does cholesteryl hemisuccinate mimic cholesterol in saturated phospholipid bilayers? Journal of Molecular Modeling (2014), 20 (2): 2121 (impact factor 1.346)
  1. Manna, M. and Mukhopadhyay, C. Binding, conformational transition and dimerization of amyloid-β peptide on GM1-containing ternary membrane: insights from molecular dynamics simulation. PLoS ONE (2013), 8 (8):e71308. (impact factor 2.740) [rated among top 25% cited articles in PLOS ONE]
  1. Manna, M. and Mukhopadhyay, C. Cholesterol driven alteration of the conformation and dynamics of phospholamban in model membranes. Physical Chemistry Chemical Physics (2011), 13(45): 20188-20198 (impact factor 3.567)
  1. Manna, M. and Mukhopadhyay, C. Molecular dynamics simulations of the interactions of Kinin peptides with an anionic POPG bilayer. Langmuir (2011), 27 (7): 3713-3722 (impact factor 3.557)
  1. Manna, M. and Mukhopadhyay, C. Cause and effect of Melittin-induced pore formation: A computational approach. Langmuir (2009), 25 (20): 12235-12242 (impact factor 3.557)



Theoretical description and computer simulations to probe the dynamic interplay between cell membrane components such as lipids, proteins, sterols and carbohydrates, implicated in cellular signalling, transport and diseases.

Computational Biophysics / Biophysical Chemistry